Guanidine compounds, and use thereof as binding partners for 5-HT5 receptors

US8481576B2 · kind B2 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Astrid Netz · Mannheim, DE
• Wilhelm Amberg · Ludwigshafen, DE
• Udo Lange · Ludwigshafen, DE
• Michael Ochse · Wiesbaden, DE
• Charles W. Hutchins · Libertyville, US
• Francisco-Xavier Garcia-Ladona · Kandel, DE
• Wolfgang Wernet · Ludwigshafen, DE
• Andreas Kling · Mannheim, DE

Key dates

• Filing date: Feb 4, 2011
• Grant date: Jul 9, 2013
• Expiry date: Feb 4, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to guanidine compounds of the general formula Icorresponding enantiomeric, diastereomeric and/or tautomeric forms thereof as well as pharmaceutically acceptable salts thereof. The present compound further relates to the use of guanidine compounds as binding partners for 5-HT5 receptors for the treatment of diseases which are modulated by a 5-HT5 receptor activity, in particular for the treatment of neurodegenerative and neuropsychiatric disorders as well as the associated signs, symptoms and dysfunctions.