Bio-degradable/absorbable polymer having reduced metal catalyst content, and process for production thereof
US8481673B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2012 |
| Grant date | Jul 9, 2013 |
| Priority date | — |
| Expiry date | Sep 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08G63/90
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a method for reducing the content of a metal catalyst in a biodegradable and absorbable polymer that can be applied on an industrial scale and a method for producing a biodegradable and bioabsorbable polymer having a metal catalyst content of less than 1 ppm in terms of a metal. The method includes the steps of (1) copolymerizing lactide and ε-caprolactone at a molar ratio ranging from 40/60 to 60/40 or 65/35 to 85/15 in the presence of the metal catalyst to produce a copolymer; and (2) washing the copolymer with a mixed solvent comprising acetic acid and isopropanol at a volume ratio ranging from 25/75 to 45/55 or 45/55 to 55/45 at less than 40° C., and drying the copolymer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.