Parallel proximity ligation event analysis
US8481698B2 · kind B2 · utility
127Cited by
26References
24Claims
0Family size
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Key dates
| Filing date | Mar 19, 2009 |
| Grant date | Jul 9, 2013 |
| Priority date | — |
| Expiry date | Apr 10, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/585
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention describes compositions and methods showing that the spatial proximity of intracellular components may be related to their ability to cooperate in intracellular biochemical reactions. In some embodiments, the present invention contemplates a variety of nucleic acid barcoded binding partners capable of determining the spatial proximity of intracellular components as determined by ligation of their respective nucleotide barcodes. As such, an intracellular component contact map may be constructed to fingerprint specific physiological and/or pharmacological intracellular conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.