Nucleic acid molecule encoding human GM-CSF antigen binding proteins

US8481704B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Jacqueline A. Kirchner · Seattle, US
• Kenneth Brasel · Philadelphia, US
• Kara Olson · White Plains, US
• Jose Carlos Escobar · Sammamish, US
• Dauphine Barone · Mill Creek, US

Key dates

• Filing date: Aug 20, 2012
• Grant date: Jul 9, 2013
• Expiry date: Aug 20, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Antigen binding proteins that bind to human GM-CSF protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of GM-CSF to GM-CSFR, inhibit GM-CSF-induced proliferation and signaling of myeloid lineage cell lines and inhibit GM-CSF-induced activation of human monocytes.