Pyrazine derivatives and uses thereof, including in medical imaging and visualization applications

US8481734B2 · kind B2 · utility

Assignee

• Medi Beacon Development, LLC · US

Inventors

• Richard B. Dorshow · Chesterfield, US
• John N. Freskos · Clayton, US
• William L. Neumann · Chesterfield, US
• Amruta Reddy Poreddy · Chesterfield, US
• Raghavan Rajagopalan · Maryland Heights, US

Key dates

• Filing date: Jan 12, 2009
• Grant date: Jul 9, 2013
• Expiry date: Jan 12, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are pyrazine derivatives of Formula I:Formula I; wherein each of X1 and X2 is independently —CONR7R9; and each of Y1 and Y2 is independently —NR48R49; and methods of using the same. The disclosed pyrazine derivatives include those having urea, amide, sulfonamide, thiourea, and/or carbamate substituents. Among the various aspects of the present invention are pyrazine derivatives that may be detected in vivo and used in a number of medical procedures (e.g., renal function monitoring). Without being bound by a particular theory, the pyrazine derivatives described herein may be designed to be hydrophilic, thus allowing for rapid renal clearance for continuous monitoring of renal function.