Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

US8481738B2 · kind B2 · utility

Assignee

• Neurocrine Biosciences, Inc. · US

Inventors

• Graham Beaton · San Diego, US
• Mi Chen · San Diego, US
• Timothy Richard Coon · Carlsbad, US
• Todd Ewing · San Diego, US
• Wanlong Jiang · San Diego, US
• Richard Lowe · Oakland, US
• Willy Moree · San Diego, US
• Nicole Smith · San Diego, US
• Warren Wade · San Diego, US
• Liren Zhao · San Diego, US
• Yun-Fei Zhu · San Diego, US
• Martin Rowbottom · San Diego, US
• Neil Ashweek · San Diego, US

Key dates

• Filing date: Nov 10, 2011
• Grant date: Jul 9, 2013
• Expiry date: Nov 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.