Method for designing an aptamer
US8484010B2 · kind B2 · utility
5Cited by
5References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 17, 2011 |
| Grant date | Jul 9, 2013 |
| Priority date | — |
| Expiry date | Nov 17, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Disclosed in this specification is a method for identifying at least one aptamer that can bind to a bio-molecular target. The aptamer is designed in silico based on the structure of the target molecule. The process includes the steps of determining a first seed residue and growing an oligomer, one residue at a time, while maximizing the entropy of target-oligomer complex or minimizing the binding energy after the addition of each oligomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.