Intramolecularly-quenched near infrared fluorescent probes
US8486373B2 · kind B2 · utility
26Cited by
43References
19Claims
0Family size
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Key dates
| Filing date | Nov 1, 2004 |
| Grant date | Jul 16, 2013 |
| Priority date | — |
| Expiry date | Dec 10, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/0068
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.