Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses

US8486374B2 · kind B2 · utility

Assignee

• Foamix Ltd. · IL

Inventors

• Dov Tamarkin · Nes Ziona, IL
• Meir Eini · Nes Ziona, IL
• Doron Friedman · Karmei Yosef, IL
• Alex Besonov · Rehovot, IL
• David Schuz · Lod, IL
• Tal Berman · Rishon LeZion, IL
• Jorge Danziger · Rishon LeZion, IL
• Rita Keynan · Rehovot, IL
• Ella Zlatkis · Rehovot, IL

Key dates

• Filing date: Jan 14, 2008
• Grant date: Jul 16, 2013
• Expiry date: Apr 8, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/38
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A waterless composition suitable for delivery of an active agent to a body surface or cavity includes a vehicle having about 70% to about 99% by weight of a hydrophilic polar solvent, said hydrophilic solvent selected from the group consisting of (i) a mixture of two or more different polyethylene glycols (PEGs), wherein at least one PEG is a high molecular weight PEG having a melting point greater than 25° C.; and (ii) propylene glycol (PG); about 0% to about 10% of at least one surface active agent; about 0% to about 5% of a polymeric agent; about 0% to about 30% of a secondary hydrophilic solvent; and about 0% to about 5% of a silicone oil; and about 3% to about 25% hydrophobic propellant. The composition is otherwise substantially free of a hydrophobic solvent and includes at least one of a surface active agent and a polymeric agent. The vehicle and the propellant are sufficiently miscible that the components may be homogeneously distributed with mild shaking.