Generation and Profiling of fully human hucal gold-derived therapeutic antibodies specific for human CD38

US8486394B2 · kind B2 · utility

Assignee

• MORPHOSYS AG · DE

Inventors

• Michael Tesar · Heidelberg, DE
• Ute Jäger · Höchst im Odenwald, DE

Key dates

• Filing date: Nov 8, 2011
• Grant date: Jul 16, 2013
• Expiry date: Nov 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/732
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides novel antibodies and functional fragments thereof specific for CD38, and methods of using the same for the treatment of diseases associated with CD38 expression, including hematological malignancies such as multiple myeloma.