Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use

US8486437B2 · kind B2 · utility

Assignee

• Angiotech Pharmaceuticals, Inc. · CA

Inventors

• George Y. Daniloff · Los Altos, US
• Michael H. Ngo · San Jose, US
• Olof Mikael Trollsas · San Jose, US
• David Gravett · Palo Alto, US
• Philip M. Toleikis · Vancouver, CA

Key dates

• Filing date: Sep 14, 2012
• Grant date: Jul 16, 2013
• Expiry date: Sep 14, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L2203/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Multifunctional compounds are provided that readily crosslink in situ to provide crosslinked biomaterials. The multifunctional compounds contain a single component having at least three reactive functional groups thereon, with the functional groups selected so as to be non-reactive in an initial environment and inter-reactive in a modified environment. Reaction of a plurality of the multifunctional compounds results in a three-dimensional crosslinked matrix. In one embodiment, a first functional group is nucleophilic, a second functional group is electrophilic, and at least one additional functional group is nucleophilic or electrophilic. Methods for preparing and using the multifunctional compounds, and kits including the multifunctional compounds are also provided. Exemplary uses for the multifunctional compounds include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.