UV stable transdermal therapeutic plaster with a UV absorbing adhesive layer separated from the drug matrix

US8486443B2 · kind B2 · utility

Assignee

• Bayer IP GmbH · DE

Inventors

• Jochen Schuhmacher · Jena, DE
• Manfred Suesse · Langenorla, DE
• Michael Dittgen · Apolda, DE
• Stephan Mletzko · Berlin, DE
• Jan-Peter Ingwersen · Berlin, DE
• Thomas Langguth · Jena, DE
• Dirk Schenk · Dietramszell, DE
• Hubert Kaffl · Munich, DE

Key dates

• Filing date: Feb 4, 2004
• Grant date: Jul 16, 2013
• Expiry date: Feb 7, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a UV stable transdermal therapeutic system (TTS) consisting of a back layer, at least one matrix containing an active substance and, optionally, a withdrawal film and an UV-radiation absorber. An adhesive layer containing said UV-radiation absorber is arranged between the back layer and the matrix containing an active substance which is distant as much as possible from a surface, a separation layer is arranged between the adhesive layer containing said UV-radiation absorber and the matrix containing an active substance, which is as remote as possible from the surface which is impermeable to the active substance and UV radiation absorber. The inventive transdermal therapeutic system exhibits a high stability and is devoid of inconveniences of existing TTS containing a light-sensitive substance.