Detecting and treating dementia
US8486635B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 30, 2007 |
| Grant date | Jul 16, 2013 |
| Priority date | — |
| Expiry date | Sep 17, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/172
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This document relates to methods and materials for detecting mutations that can be linked to dementia. For example, methods and materials for detecting one or more mutations within PGRN nucleic acid are provided. This document also provides methods and materials for detecting the level of progranulin expression. In addition, this document relates to methods and materials for treating mammals having a neurodegenerative disorder (e.g., dementia). For example, methods and materials for increasing PGRN polypeptide levels in mammals are provided, as are methods and materials for identifying agents that can be used to increase PGRN polypeptide levels in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.