Synthetic peptide amides and dimeric forms thereof
US8486894B2 · kind B2 · utility
48Cited by
12References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 5, 2010 |
| Grant date | Jul 16, 2013 |
| Priority date | — |
| Expiry date | Jun 26, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K7/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure:wherein Xaa is a D-amino acid and G is selected from the following three groups:The compounds are useful in the prophylaxis and treatment of pain, pruritis and inflammation associated with a variety of diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.