Synthesis of tetracyclines and analogues thereof
US8486921B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 6, 2007 |
| Grant date | Jul 16, 2013 |
| Priority date | — |
| Expiry date | May 12, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/52
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetra-cycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-pro liferative agents in the treatment of diseases of humans or other animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.