Pyrimidine inhibitors of kinase activity

US8486933B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Gary T. Wang · Libertyville, US
• Robert A. Mantei · Franklin, US
• Scott A. Erickson · Zion, US
• Steve D. Fidanze · Grayslake, US
• George S. Sheppard · Wilmette, US
• Jieyi Wang · Lake Bluff, US
• Randy L. Bell · Lindenhurst, US

Key dates

• Filing date: May 26, 2010
• Grant date: Jul 16, 2013
• Expiry date: Jun 14, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof,wherein L1, R1, R2, R3, R4, R5, and m are defined in the description. Methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as IGF-1R are also disclosed.