Piperazinodihydrothienopyrimidine derivatives

US8486948B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Pascale Pouzet · Biberach, DE
• Christoph Hoenke · Ingelheim am Rhein, DE
• Peter Nickolaus · Warthausen, DE
• Rolf Goeggel · Ulm, DE
• Thomas Fox · Biberach, DE
• Dennis Fiegen · Biberach an der Riß, DE
• Klaus Klinder · Oggelshausen, DE

Key dates

• Filing date: Oct 16, 2008
• Grant date: Jul 16, 2013
• Expiry date: Sep 8, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the novel dihydrothienopyrimidine sulfoxides of formula (I) and to the pharmacologically acceptable salts thereof, wherein X represents SO or SO2, preferably however SO, and wherein R3, R4, R4′, R5, R6 and R7 are defined as in claim 1. The invention also relates to pharmaceutical compositions containing said compounds. The novel dihydrothienopyrimidine sulfoxides are suitable for use in the treatment of respiratory or gastrointestinal disorders or diseases, inflammatory diseases of the joints, the skin or the eyes, diseases of the peripheral or central nervous system or cancers.