Method for the direct elution of reactive 18F fluoride from an anion exchange resin in an organic medium suitable for radiolabelling without any evaporation step by the use of strong organic bases

US8491790B2 · kind B2 · utility

Assignees

• TRASIS S.A. · BE
• UNIVERSITÉ DE LIÈGE · BE

Inventors

• Christian Lemaire · Alleur, BE
• Samuel Voccia · Liège, BE
• Joël Aerts · Durbuy, BE
• André Luxen · Ocquier, BE
• Jean-Luc Morelle · Liège, BE
• Gauthier Philipart · Grand-Rechain, BE

Key dates

• Filing date: Jul 1, 2008
• Grant date: Jul 23, 2013
• Expiry date: Mar 18, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01D15/363
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

A method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step wherein the eluting solution is a organic solution having a water content <3%. The solution contains at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of the first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).