Imaging agents for detecting neurological disorders

US8491869B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Umesh B. Gangadharmath · Los Angeles, US
• Hartmuth C. Kolb · El Segundo, US
• Peter J. H. Scott · Ypsilanti, US
• Joseph C. Walsh · Santa Monica, US
• Wei Zhang · San Diego, US
• Anna Katrin Szardenings · San Diego, US
• Anjana Sinha · San Diego, US
• Gang Chen · Sammamish, US
• Eric Wang · Yonkers, US
• Vani P. Mocharia · Los Angeles, US
• Chul Yu · Los Angeles, US
• Changhui Liu · Los Angeles, US
• Daniel K. Cashion · San Diego, US
• Dhanalakshmi Kasi · Los Angeles, US

Key dates

• Filing date: Mar 23, 2010
• Grant date: Jul 23, 2013
• Expiry date: Mar 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering ti a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.