Patent · US Active

Human beta-glucuronidase mutants with elevated enzymatic activity under physiological conditions and method for identifying such

US8491891B2 · kind B2 · utility

7Cited by

1References

11Claims

0Family size

Assignee

ACADEMIA SINICA · TW

Inventors

Steve Roffler · Taipei, TW
Chia-Hung Wu · Zhongshan, CN
Wolfgang Schechinger · Dieburg, DE
Kai Chen · Rockville, US
Zeljko M. Prijovic · Umka, RS

Key dates

Filing date	Nov 25, 2009
Grant date	Jul 23, 2013
Priority date	—
Expiry date	Jun 23, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S424/809
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A number of human beta-glucuronidase variants having higher enzymatic activity at physiological pH as compared with wild-type beta-glucuronidase and uses thereof in prodrug therapy. Also disclosed herein is a method for identifying enzyme variants having elevated enzymatic activity using a mammalian surface display system.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.