Expression of toxic genes in vivo in a non-natural host
US8492117B2 · kind B2 · utility
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4References
16Claims
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Key dates
| Filing date | Dec 3, 2007 |
| Grant date | Jul 23, 2013 |
| Priority date | — |
| Expiry date | Feb 15, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions and methods are provided for expression of a toxic protein in a host cell preferably a bacterial host cell where at least one T7 RNA polymerase gene Is contained on the host cell chromosome and one or more genes encoding a T7 RNA polymerase inhibitor is located on an F′ plasmid or on the chromosome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.