Bacillus coagulans strains and their applications in L-lactic acid production

US8492127B2 · kind B2 · utility

Assignee

• Shanghai Jiao Tong University · CN

Inventors

• Ping Xu · Osaka, JP
• Limin Wang · San Diego, US
• Bo Zhao · Jingwei, CN
• Cuiqing Ma · Shanghai, CN
• Fei Su · Shanghai, CN
• Fei Tao · Shanghai, CN
• Hongzhi Tang · Shanghai, CN

Key dates

• Filing date: Nov 22, 2010
• Grant date: Jul 23, 2013
• Expiry date: Nov 22, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/07
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention is concerned with the strains of B. coagulans for lactic acid production and the related methods, in which the carbon sources are pentose or hexose or the agricultural or industrial wastes containing pentose or hexose or a mixture of both. According to the invention, the highest amount of L-lactic acid produced from glucose is 173 g/L, the optical purity is over 99%, the yield is up to 0.98, and the productivity is up to 2.4 g/L per hour. The highest amount of L-lactic acid produced from xylose is 195 g/L, the optical purity is over 99%, the yield is up to 0.98, and the productivity is up to 2.7 g/L per hour. The highest amount of L-lactic acid produced from reducing sugars in xylitol byproducts is 106 g/L, the optical purity is over 99%, and the productivity is up to 2.08 g/L per hour. The B. coagulans strains XZL4 (DSM No. 23183) and XZL9 (DSM No. 23184) of the invention can directly utilize various reducing sugars in xylitol byproducts to produce high amounts of L-lactic acid, which improves the production efficiency at low costs, and the strains are, thus, appropriate for industrial productions.