Production of conjugates
US8492129B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 2006 |
| Grant date | Jul 23, 2013 |
| Priority date | — |
| Expiry date | May 24, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6815
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of reacting a first chemical entity and a second chemical entity to form a conjugate in which the first and second chemical entities are covalently bound with respect to each other, comprises bringing into simultaneous contact the first chemical entity, the second chemical entity and a thiol generator, wherein the thiol generator reacts with the first chemical entity in a thiolation reaction resulting in formation of a free sulfhydryl group on the first chemical entity, and the free sulfhydryl group reacts with the second chemical entity to form the conjugate, and wherein the second chemical entity is polyvalent with respect to its reactivity with sulfhydryl groups. The present invention primarily differs from the prior art in that no separation step is involved between reaction of the thiol generator and first chemical entity and reaction with the second chemical entity. The invention also provides a conjugation kit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.