Biomarker sensors and method for multi-color imaging and processing of single-molecule life signatures

US8492160B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Administrator of the National Aeronautics and Space Administration · US

Inventors

• Lawrence A. Wade · Fremont, US
• Charles Patrick Collier · San Marino, US

Key dates

• Filing date: Mar 9, 2010
• Grant date: Jul 23, 2013
• Expiry date: Apr 9, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01Q80/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention is a device including array of aciive regions for use in reacting one or more species in at least two of the active regions in a sequential process, e.g., sequential reactions. The device has a transparent substrate member, which has a surface region and a silane material overlying the surface region. A first active region overlies a first portion of the silane material. The first region has a first dimension of less than 1 micron in size and has first molecules capable of binding to the first portion of the silane material. A second active region overlies a second portion of the silane material. The second region has a second dimension of less than 1 micron in size, second molecules capable of binding to the second portion of the active region, and a spatial distance separates the first active region and the second active region.