Patent · US Active

Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin A

US8492349B2 · kind B2 · utility

9Cited by

2References

7Claims

0Family size

Assignee

Pain Therapeutics, Inc. · US

Inventors

Hoau-Yan Wang · Philadelphia, US
Lindsay Burns Barbier · Austin, US
Jian Wang · Daitou, CN

Key dates

Filing date	Feb 29, 2012
Grant date	Jul 23, 2013
Priority date	—
Expiry date	Feb 29, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/665
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W—[X1X2X3 . . . X43X44X45]nValAlaX48GlyLeu[X51X52X53 . . . X94X95X96]m—Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.