7-substituted tetracycline compounds

US8492365B2 · kind B2 · utility

Assignees

• Trustees of Tufts College · US
• Paratek Pharmaceuticals, Inc. · US

Inventors

• Mark L. Nelson · Norfolk, US
• Roger Frechette · Somerville, US
• Peter Viski · Brookline, US
• Mohamed Y. Ismail · Bedford, US
• Todd Bowser · Charlton, US
• Beena Bhatia · Mansfield, US
• David Messersmith · Somerville, US
• Laura McIntyre · Arlington, US
• Darrell J. Koza · Westerly, US
• Glen Rennie · Somerville, US
• Paul Sheahan · San Diego, US
• Paul Hawkins · Cambridge, US
• Atul K. Verma · Mansfield, US
• Tadeusz Warchol · Northborough, US
• Upul K. Bandarage · Lexington, US

Key dates

• Filing date: Jun 9, 2009
• Grant date: Jul 23, 2013
• Expiry date: Nov 29, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.