Antibacterial agents

US8492414B2 · kind B2 · utility

Assignee

• BIOTA SCIENTIFIC MANAGEMENT PTY LTD · AU

Inventors

• David John Haydon · Yarnton, GB
• Ian Collins · Ware, GB
• Lloyd George Czaplewski · Yarnton, GB

Key dates

• Filing date: Sep 22, 2008
• Grant date: Jul 23, 2013
• Expiry date: Dec 22, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P33/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (IA) or (IB) have antibacterial activity: wherein W is ═CH— or ═N—; Ri and R2 are independently selected from hydrogen, fluoro and chloro, provided that Ri and R2 are not each hydrogen when W is ═CH—; n is 0 or 1; X is —O—, —S—, or —CH2—; and Q is (i) a phenyl radical, a naphthyl radical, a monocyclic carbocyclic or heteroaryl radical having 3 to 6 ring atoms, or a bicyclic heteroaryl radical having 5 to 10 ring atoms, any of which radicals being optionally substituted; or (ii) an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl radical, which may optionally be interrupted by —O—, —S—, —S(O)—, —S(O2)—, —NH—, —N(CH3)—, —N(CH2CH3)—, —C—K═Oh or —C(═O)—O—.