Difluorophenyldiacylhydrazide derivatives

US8492440B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Thomas Fuchss · Bensheim, DE
• Ulrich Graedler · Weinheim, DE
• Norbert Beier · Reinheim, DE
• Rolf Gericke · Seeheim-Jugenheim, DE
• Florian Lang · Gilching, DE

Key dates

• Filing date: Nov 2, 2009
• Grant date: Jul 23, 2013
• Expiry date: May 18, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel difluorophenyldiacylhydrazide derivatives of the formula I, in which R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, are kinase inhibitors and can be used for the treatment of diseases and complaints such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and kidney diseases, generally in any type of fibroses, inflammatory processes, tumours and tumour diseases.