Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone

US8492532B2 · kind B2 · utility

Assignee

• The Research Foundation For Microbial Diseases of Osaka University · JP

Inventors

• Kouichi Morita · Nagasaki, JP
• Takeshi Nabeshima · Nagasaki, JP
• Shinichi Miyake · Kanonji, JP
• Toshiyuki Onishi · Samukawa, JP
• Isao Fuke · Samukawa, JP
• Toyokazu Ishikawa · Abashiri, JP
• Hideo Goda · Kanonji, JP
• Masahide Ishibashi · Kanonji, JP
• Michiaki Takahashi · Osaka, JP

Key dates

• Filing date: Nov 20, 2008
• Grant date: Jul 23, 2013
• Expiry date: Sep 15, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.