Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US8492539B2 · kind B2 · utility
33Cited by
101References
7Claims
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Key dates
| Filing date | Sep 13, 2005 |
| Grant date | Jul 23, 2013 |
| Priority date | — |
| Expiry date | Dec 8, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.