Patent · US Active

Process for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses

US8492590B2 · kind B2 · utility

1Cited by

3References

13Claims

0Family size

Assignee

BAYER CROPSCIENCE AKTIENGESELLSCHAFT · DE

Inventors

Mark James Ford · Nordenstadt, DE
Gunter Karig

Key dates

Filing date	Apr 28, 2010
Grant date	Jul 23, 2013
Priority date	—
Expiry date	Aug 1, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C323/58
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4):where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W):in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above −65° C.In a subsequent process, this compound is further reacted in the presence of an acid catalyst to give the indole of formula (7) or the oxindole of formula (8):

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.