GNTIII expression in plants

US8492613B2 · kind B2 · utility

Assignee

• Stichting Dienst Landbouwkundig Onderzoek-PPO/PRI · NL

Inventors

• Hendrikus Antonius Cornelis Bakker · Hannover, DE
• Dionisius Elisabeth Antonius Florack · Wageningen, NL
• Hendrik Jan Bosch · Utrecht, NL

Key dates

• Filing date: Dec 29, 2010
• Grant date: Jul 23, 2013
• Expiry date: Dec 29, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P21/02
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.