Delivery of nucleic acid-like compounds

US8496961B2 · kind B2 · utility

Assignee

• SUTTER WEST BAY HOSPITALS · US

Inventors

• Keelung Hong · Mill Valley, US
• Wei Zheng · Las Vegas, US
• Daryl C. Drummond · Lincoln, US
• Dmitri B. Kirpotin · San Francisco, US
• Mark E. Hayes · Mill Valley, US

Key dates

• Filing date: May 15, 2003
• Grant date: Jul 30, 2013
• Expiry date: Oct 8, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for preparing a microparticulate complex is provided. The process comprises (a) combining a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible, organic solvent to form a mixture wherein the PFC and the NAC are independently molecularly or micellarly soluble in the aqueous/organic solvent system, and (b) reducing the amount of the organic solvent in the mixture. This effects formation of the microparticulate complex of the NAC and the PFC. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component forming an approximately spherical particle, wherein the particle-forming component encloses an interior of the particle containing the nucleic acid-like component and the so-enclosed interior volume has less than about 50% (preferably less than 20%) of the volume containing free water.