Methods for determining signal transduction activity in tumors
US8497080B2 · kind B2 · utility
1Cited by
20References
12Claims
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Key dates
| Filing date | Feb 5, 2013 |
| Grant date | Jul 30, 2013 |
| Priority date | — |
| Expiry date | Feb 5, 2033 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The method of the invention pertains to determining signal transduction activity in a tissue section by immunohistochemistry techniques. The expression level of the receptor of interest is determined as well as the expression levels of one or more effector molecules of the receptor signal transduction pathway. Furthermore a combined ratio of expression levels of effector molecules in subcellular compartments with the receptor expression was found to have prognostic significance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.