Macrocyclic integrase inhibitors

US8497270B2 · kind B2 · utility

Assignee

• Elanco Animal Health Ireland Limited · US

Inventors

• Johannes Wilhelmus John F. Thuring · Ekeren, BE
• Jean-François Bonfanti · Andé, FR
• Jérôme Michel Claude Fortin · Igoville, FR

Key dates

• Filing date: Oct 13, 2010
• Grant date: Jul 30, 2013
• Expiry date: Oct 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compound having formula (I), wherein —W is NH—, —N(CH3)— or piperazine, —X is a bond, —C(═O)— or S(═O)2—, —Y is C3-7alkylene, and —Z is NH—C(═O)— or —O—, and pharmaceutically acceptable salts thereof, their pharmaceutical formulations and use as HIV inhibitors.