Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases

US8497294B2 · kind B2 · utility

Assignees

• ASTEX THERAPEUTICS LIMITED · GB
• The Institute of Cancer Research: Royal Cancer Hospital · GB
• Cancer Research Technology Limited · GB

Inventors

• Steven John Woodhead · San Diego, US
• David Charles Rees · Cambridge, GB
• Kyla Merriom Grimshaw · Cambridge, GB

Key dates

• Filing date: Jul 11, 2011
• Grant date: Jul 30, 2013
• Expiry date: Jul 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D231/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a composition comprising (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.