Patent · US Active

Method to enhance aqueous solubility of poorly soluble actives

US8497303B2 · kind B2 · utility

7Cited by

20References

10Claims

0Family size

Assignee

DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

David B. Wurn · Pearland, US
David A. Wilson · Lake Jackson, US
Bruce A. Barner · Alum Creek, US
Cynthia L. Rand · Sanford, US
Matthew D. Miller · Lake Jackson, US
Michael J. Johnson · Orlando, US

Key dates

Filing date	Jan 5, 2009
Grant date	Jul 30, 2013
Priority date	—
Expiry date	Jan 9, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K47/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A method to enhance solubility of an active compound comprises combining an active compound, having an aqueous solubility that is less than or equal to about 10 mg/mL, and an amount of methoxypolyethylene glycol that is sufficient to increase the aqueous solubility of the active compound. Enhancement of aqueous solubility for this combination may be significantly greater than that of an active compound in combination with an equivalent amount of polyethylene glycol. Particularly enhanced solubility is shown where a small amount of water is also included. The invention may be used in a wide variety of applications, such as for pharmaceutical, agricultural, antimicrobial, and personal care products.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.