Magnetic resonance method for quantification of molecular diffusion using double echo steady state sequences
US8497680B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 24, 2011 |
| Grant date | Jul 30, 2013 |
| Priority date | — |
| Expiry date | Jan 16, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/5614
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed is a magnetic resonance method for the quantification of molecular diffusion. The method uses a diffusion-weighted (dw) double echo steady state sequence (DESS). In particular, the method allows direct quantification of molecular diffusion from two steady state scans with differing diffusion weighting such as one with diffusion-weighting and preferably one without diffusion weighting. Such a quantification of molecular diffusion allows for rapid and/or quantitative measurements of physiological and/or functional parameters of living tissue. Quantitative measurements are often a prerequisite for pre-clinical and clinical research as well as for clinical trials in drug research performed at different sites. Especially for the early diagnosis of subtle or diffuse pathological changes, quantitative MR promises to have a very significant impact.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.