Microorganisms for improving the health of individuals with disorders related to gluten ingestion

US8501169B2 · kind B2 · utility

Assignee

• Consejo Superior de Investigaciones Cientificas (CSIC) · ES

Inventors

• Yolanda Sanz Herranz · Burjassot, ES
• Esther Sanchez Sanchez · Burjassot, ES
• Marcela Susana Medina · Burjassot, ES
• Giada De Palma · Burjassot, ES
• Inmaculada Nadal Gimenez · Burjassot, ES

Key dates

• Filing date: Dec 23, 2008
• Grant date: Aug 6, 2013
• Expiry date: Jan 11, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A23V2002/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to microorganisms for the treatment of food allergies, specifically coeliac disease, as well as to methods for the selection thereof. The action mechanisms of said microorganisms include: (i) the regulation of the innate and adaptive immunological responses; (ii) the reduction of the concentration of toxic gluten peptide epitopes in the intestinal lumen; (iii) the strengthening of the barrier defence function against harmful antigens and bacteria; and (iv) the provision of enzymatic activities that promote digestion.