Enantioselective reactions catalyzed by chiral triazolium salts
US8501658B2 · kind B2 · utility
0Cited by
2References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 23, 2007 |
| Grant date | Aug 6, 2013 |
| Priority date | — |
| Expiry date | Apr 3, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D407/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides a convenient method for converting imines and other electrophiles into heterocyclic ring systems. The process does not require the use of metallic reagents, and is catalyzed by an organic heterocyclic carbene catalyst. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. Chiral heterocyclic carbene catalysts of the invention and methods of using these catalysts produce chiral heterocycles in high enantiomeric and diastereomeric excess.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.