Isoquinoline derivatives

US8501736B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Oliver Plettenburg · Kelkheim, DE
• Armin Hofmeister · Frankfurt, DE
• Dieter Kadereit · Kelkheim, DE
• Stefan Peukert · Frankfurt am Main, DE
• Sven Ruf · Mainz, DE
• Kurt Ritter · Heidelberg, DE
• Matthias Loehn · Frankfurt am Main, DE
• Yuri Ivashchenko · Hattersheim, DE
• Peter Monecke · Darmstadt, DE
• Matthias Dreyer · Frankfurt am Main, DE
• Aimo Kannt · Dreieich, DE

Key dates

• Filing date: Dec 20, 2007
• Grant date: Aug 6, 2013
• Expiry date: Apr 20, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 6-piperidinyl-substituted isoquinoline derivatives of the formula (I)useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.