Piperidinyl derivatives as modulators of chemokine receptor activity

US8501782B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Daniel S. Gardner · Furlong, US
• John V. Duncia · Newtown, US
• John Hynes · Washington Crossing, US
• T.G. Murali Dhar · Carbondale, US
• Percy H. Carter · Princeton, US
• Joseph B. Santella · Springfield, US

Key dates

• Filing date: Jul 23, 2008
• Grant date: Aug 6, 2013
• Expiry date: Jul 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application describes modulators of MIP-1α of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators of formula (I) are disclosed.