Compounds for the inhibition of angiogenesis and use thereof

US8501787B2 · kind B2 · utility

Assignee

• Shire Orphan Therapies GmbH · DE

Inventors

• Grit Zahn · Berlin, DE
• Roland Stragies · Berlin, DE
• Frank Osterkamp · Berlin, DE
• Gunther Zischinsky · Berlin, DE
• Jochen Knolle · Kriftel, DE
• Gerd Hummel · Berlin, DE
• Sascha Birkner · Essen, DE
• Ulrich Reineke · Berlin, DE

Key dates

• Filing date: Mar 24, 2005
• Grant date: Aug 6, 2013
• Expiry date: Aug 5, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to compounds of structure (I). Particularly this invention is directed to compounds of structure (VIII) wherein the variables are defined as in the description. These compounds are integrin inhibitors and are useful in the treatment of diseases in which an inhibition of angiogenesis is desired.