Polypeptides having affinity for HER2

US8501909B2 · kind B2 · utility

Assignee

• AFFIBODY AB · SE

Inventors

• Lars Abrahmsen · Bromma, SE
• Nina Herne · Stockholm, SE
• Joachim Feldwisch · Tyresö, SE
• Christofer Lendel · Älta, SE
• Vladimir Tolmachev · Uppsala, SE

Key dates

• Filing date: Dec 22, 2008
• Grant date: Aug 6, 2013
• Expiry date: Dec 3, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

HER2 binding polypeptides comprising the amino acid sequence EX1 RNAYWEIA LLPNLTNQQK RAFIRKLYDD PSQSSELLX2E AKKLNDSQ wherein X1 in position 2 is M, I or L, and X2 in position 39 is S or C (SEQ ID NO: 1) are disclosed. Moreover, such peptides comprising a chelating environment are disclosed. Also radiolabeled polypeptides formed by the peptides comprising a chelating environment and radionuclides are disclosed. Furthermore, methods of in vivo imaging of the body of a mammalian subject having or suspected of having a cancer characterized by overexpression of HER2 comprising administration of such a radiolabeled polypeptide followed by obtainment of an image of the body using a medical imaging instrument and also methods of treating such cancer are disclosed. Furthermore, the use of such a radiolabeled polypeptide in diagnosis and treatment of cancer characterized by overexpression of HER2. Nucleic acids encoding the polypeptides, expression vectors comprising the nucleic acids and host cells comprising the expression vectors are also disclosed.