Malaria vaccine

US8501926B2 · kind B2 · utility

Assignees

• THE JOHNS HOPKINS UNIVERSITY · US
• The United States of America as represented by the Secretary of the Army · US

Inventors

• Nirbhay Kumar · Bethesda, US
• Evelina Angov · Bethesda, US

Key dates

• Filing date: Jul 22, 2009
• Grant date: Aug 6, 2013
• Expiry date: Jul 22, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features immunogenic compositions based on pre-fertilization or post-fertilization antigens expressed in the circulating gametocytes in the peripheral blood of infected persons or on the malaria parastes' stages of development in the mosquito midgut including extracellular male and female gametes, fertilized zygote and ookinete. The invention also features methods to prevent the transmission of malaria using the immunogenic compositions of the invention.