Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists

US8501933B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Li Chen · Sha Tin, CN
• Michael Patrick Dillon · Mill Valley, US
• Lichun Feng · Shanghai, CN
• Ronald Charles Hawley · Oakland, US
• Minmin Yang · Nanjing, CN

Key dates

• Filing date: Jul 26, 2010
• Grant date: Aug 6, 2013
• Expiry date: Mar 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I:or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B,and X, R2, R3, R4, R5, R6, Ra and Rb are as defined herein. Also provided are methods of using the compounds for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist and methods of making the subject compounds.