Pegylated fluorobenzamide analogues, their synthesis and use in diagnostic imaging
US8506927B2 · kind B2 · utility
1Cited by
3References
20Claims
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Key dates
| Filing date | Jan 5, 2012 |
| Grant date | Aug 13, 2013 |
| Priority date | — |
| Expiry date | Apr 13, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D217/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pegylated fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labeled with a positron-emitting radioisotope such as 18F, can be used as radiotracers for medical imaging such as imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labeled with 123I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.