Method for adjuvanting lipopolysaccharide (LPS) of gram-negative bacteria
US8506971B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 2010 |
| Grant date | Aug 13, 2013 |
| Priority date | — |
| Expiry date | Nov 14, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6068
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject of the invention is a method for adjuvanting LPS of a Gram-negative bacterium, according to which LPS or LPS liposomes (LPS formulated in liposomes) is (are) mixed with the lipidated human-transferrin receptor subunit B (TbpB protein) of Neisseria meningitidis or a lipidated fragment thereof; or (ii) LPS and the lipidated TbpB of N. meningitidis or a lipidated fragment thereof are formulated together in liposomes; or (iii) LPS is conjugated with the lipidated TbpB of N. meningitidis or a lipidated fragment thereof; in order to obtain a preparation which does not contain OMVs and which is capable of inducing, after administration to a mammal, an anti-LPS immune response which is improved by comparison with the anti-LPS immune response observed after administration of the corresponding preparation in which the lipidated TbpB of N. meningitidis or a lipidated fragment thereof is omitted; as well as vaccine compositions thereof. The LPS may, for example, be the LOS of a non-enteric Gram-negative bacterium such as N. meningitidis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.