Compressed tablets comprising microcapsules with modified release
US8507003B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 14, 2003 |
| Grant date | Aug 13, 2013 |
| Priority date | — |
| Expiry date | Jul 16, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5073
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.