Process for the expression of peptides of interest using GCSF as a fusion partner
US8507221B2 · kind B2 · utility
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27Claims
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Key dates
| Filing date | Sep 22, 2008 |
| Grant date | Aug 13, 2013 |
| Priority date | — |
| Expiry date | Jul 28, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.